A Case of infiltrating lobular carcinoma of the breast with gastric metastasis 22 years after initial surgery

01 March 2021


Mohammad Hanafiah, Sabrilhakim Sidek, Soo Fin Low and Chai Soon Ngiu

复制引用
已复制!

摘要

Gastric metastasis from breast carcinoma is uncommon and rarely encountered in our daily practice. We report a case of late gastric metastasis from previous infiltrating lobular carcinoma of the breast. The patient had extended disease-free interval of 22 years prior to metastasis. Gastroscopy and fluoroscopy showed changes appearing like linitis plastica of the body of the stomach. Computed tomography of the thorax and abdomen demonstrated pulmonary metastasis and mediastinal lymphadenopathy. Biopsy of the mediastinal lymph node and stomach lesion confirmed metastatic adenocarcinoma from breast carcinoma based on immunohistochemistry staining. Immunohistochemistry staining of both specimens revealed strong positivity for cytokeratin 7 and negative for cytokeratin 20.


参考资料

  1. Žitnjak D, Soldić Ž, Kust D, Bolanča A, Kusić Z. Demographic and clinicopathologic features of patients with primary breast cancer treated between 1997 and 2010: a single-institution experience. Acta Clin Croat. 2015;54(3):295–302.
  2. Yoon SK, Dong WR, Chung HL. Peritoneal and gastric metastasis from invasive lobular breast carcinoma: a case report. Kosin Med J. 2015;30(1):87–92. doi:10.7180/kmj.2015.30.1.87
  3. Ambroggi M, Stroppa EM, Mordenti P, et al. Metastatic breast cancer to the gastrointestinal tract: report of five cases and review of the literature. Int J Breast Cancer. 2012;2012:439023. doi:10.1155/2012/439023
  4. Taal BG, Peterse H, Boot H. Clinical presentation, endoscopic features, and treatment of gastric metastases from breast carcinoma. Cancer. 2000;89(11):2214–2221. doi:10.1002/1097-0142(20001201)89:11<2214::AID-CNCR9>3.0.CO;2-D
  5. Washington K, McDonagh D. Secondary tumors of the gastrointestinal tract: surgical pathologic findings and comparison with autopsy survey. Mod Pathol. 1995;8(4):427–433.
  6. Tan L, Piao Y, Liu Z, et al. Breast cancer metastasis to the stomach confirmed using gastroscopy: a case report. Oncol Lett. 2014;8(3):1205–1207. doi:10.3892/ol.2014.2260
  7. Carcoforo P, Raiji MT, Langan RC, et al. Infiltrating lobular carcinoma of the breast presenting as gastrointestinal obstruction: a mini review. J Cancer. 2012;3:328–332. doi:10.7150/jca.4735
  8. Mahmud N, Ford JM, Longacre TA, et al. Metastatic lobular breast carcinoma mimicking primary signet ring adenocarcinoma in a patient with a suspected CDH1 mutation. J Clin Oncol. 2015;33(4):e19–e21. doi:10.1200/JCO.2013.49.1159
  9. Broom RJ, Tang PA, Simmons C, et al. Changes in estrogen receptor, progesterone receptor and HER2/neu status with time: discordance rates between primary and metastatic breast cancer. Anticancer Res. 2009;29(5):1557–1562.
  10. Switzer N, Lim A, Du L, et al. Case series of 21 patients with extrahepatic metastatic lobular breast carcinoma to the gastrointestinal tract. Cancer Treat Commun. 2015;3:37–43. doi:10.1016/j.ctrc.2014.11.006
  11. Hara F, Kiyoto S, Takabatake D, et al. Metastatic breast cancer to the stomach resembling early gastric cancer. Case Rep Oncol. 2010;3(2):142–147. doi:10.1159/000313923
  12. Miše I, Vučić M, Maričević I, et al. Histologic subtypes of invasive lobular carcinoma in correlation with tumor status and hormone receptors. Acta Clin Croat. 2010;49(3):275–281.
  13. Kojima O, Takahashi T, Kawakami S, et al. Localization of estrogen receptors in gastric cancer using immunohistochemical staining. Cancer. 1991;67(9):2401–2406. doi:10.1002/1097-0142(19910501)67:9<2401::AID-CNCR2820670931>3.0.CO;2-H
  14. O’Connell FP, Wang HH, Odze RD. Utility of immunohistochemistry in distinguishing primary adenocarcinomas from metastatic breast carcinomas in the gastrointestinal tract. Arch Pathol Lab Med. 2005;129(3):338–347. doi:10.5858/2005-129-338-UOIIDP

引用

Hanafiah, M., Sidek, S., Low, S. F., & Ngiu, C. S. (2021). A CASE OF INFILTRATING LOBULAR CARCINOMA OF THE BREAST WITH GASTRIC METASTASIS 22 YEARS AFTER INITIAL SURGERY. Acta clinica Croatica60(1), 136–140. https://doi.org/10.20471/acc.2021.60.01.20

复制引用 已复制!