吉隆坡一项回顾性研究:面部和颈部湿疹患者的接触致敏模式

01 September 2024


Hock Gin Teo, Sharifah Rosniza Syed Nong Chek, Min Moon Tang

复制引用
已复制!

摘要

Introduction

Allergic contact dermatitis (ACD) involving the face and neck region (FNR) is not uncommon. We aimed to determine the sensitisation pattern among patients with dermatitis involving FNR who underwent skin patch tests between 2016 and 2022.

Materials and methods

This is a 7-year retrospective review on contact sensitisation patterns in patients with dermatitis over the FNR who underwent skin patch tests between 2016 and 2022 in the Department of Dermatology Hospital Kuala Lumpur.

Results

There were 291 patients (female-to-male ratio of 7.8:1; mean age of 34.1 ± 14.0 years) with dermatitis at the FNR who underwent patch tests. The majority (n = 116,39.9%) were aged between 20 and 29 years. About 8% were below 19 years of age. Nearly 50% had dermatitis over the perioral region, 8.6% at the periorbital area and 50.6% at the other parts of the face and neck region. The clinical diagnoses included contact dermatitis (n = 145, 49.8%), cheilitis (n = 81, 27.8%), endogenous eczema (n = 28, 9.6%) and others. All were tested with European baseline series, with 91.4% and 77.0% tested with extended series, and own products, respectively. About 70.1% were sensitised to at least one allergen. The most common sensitizing allergen was nickel sulfate (34.0%), followed by cobalt chloride (11.7%), fragrance mix (10.7%), methylchloroisothiazolinone/ methylisothiazolinone (8.9%), and formaldehyde (8.9%). Clinical relevance was documented in 58.8% of them.

Conclusion

Contact sensitisation was detected in about 70% of patients with dermatitis at the FNR who were patchtested. Nickel, cobalt chloride and fragrance mix were the most common sensitising allergens in these patients.


参考资料

  1. Aquino M, Rosner G. Systemic contact dermatitis. Clin Rev Allergy Immunol 2019; 56: 9-18.
  2. Contento M, Maher J, Cline A, Rose S. Why does facial eczema differ from body eczema? J Drugs Dermatol 2022; 21: 1119-23.
  3. Scheinman PL, Vocanson M, Thyssen JP, Johansen JD, Nixon RL, Dear K et al. Contact dermatitis. Nat Rev Dis Primers 2021; 7: 38. 
  4. Adişen E, Onder M, Terzioglu Y. A retrospective study of patients with facial allergic contact dermatitis patch tested with the European standard series in Turkey. J Eur Acad Dermatol Venereol 2009; 23: 704-5.
  5. Garg T, Agarwal S, Chander R, Singh A, Yadav P. Patch testing in patients with suspected cosmetic dermatitis: a retrospective study. J Cosmet Dermatol 2018; 17: 95-100.
  6. Kasemsarn P, Iamphonrat T, Boonchai W. Risk factors and common contact allergens in facial allergic contact dermatitis patients. Int J Dermatol 2016; 55: 417-24.
  7. Li LF, Liu G, Wang J. Prevalence and 1-year outcome of facial allergic contact dermatitis in patients patch tested in a university hospital. Contact Dermat 2007; 57: 187-90.
  8. Katz AS, Sherertz EF. Facial dermatitis: patch test results and final diagnoses. Am J Contact Dermat 1999; 10: 153-6.
  9. Ficheux AS, Wesolek N, Chevillotte G, Roudot AC. Consumption of cosmetic products by the French population. First part: frequency data. Food Chem Toxicol 2015; 78: 159-69.
  10. Brenaut E, Nezet P, Misery L, Legeas C, Roudot AC, Ficheux AS. Use of cosmetic products in real life by women with facial sensitive skin: results from an exposure study and comparison with controls. Skin Pharmacol Physiol 2021; 34: 363-74.
  11. Meding B. Differences between the sexes with regard to workrelated skin disease. Contact Dermat 2000; 43: 65-71.
  12. Tramontana M, Bianchi L, Hansel K, Agostinelli D, Stingeni L. Nickel allergy: epidemiology, pathomechanism, clinical patterns, treatment and prevention programs. Endocr Metab Immune Disord Drug Targets 2020; 20: 992-1002.
  13. Goh CL, Ng SK, Kwok SF. Allergic contact dermatitis from nickel in eyeshadow. Contact Dermat 1989; 20: 380-1.
  14. Symanzik C, Uter W, Becker SM, Skudlik C, John SM. Nickel and cobalt release from beauty tools: a field study in the German cosmetics trade. Contact Dermat 2022; 87: 162-9.
  15. Duarte I, Mendonça RF, Korkes KL, Lazzarini R, Hafner MFS. Nickel, chromium and cobalt: the relevant allergens in allergic contact dermatitis. Comparative study between two periods: 1995-2002 and 2003-2015. An Bras Dermatol 2018; 93: 59-62.
  16. Silverberg JI, Patel N, Warshaw EM, Maibach HI, Belsito DV, DeKoven JG, et al. Patch testing with cobalt in children and adolescents: North American contact dermatitis group experience, 2001-2018. Contact Dermat 2022; 87: 420-9.
  17. Johansen JD. Fragrance contact allergy: a clinical review. Am J Clin Dermatol 2003; 4: 789-98.
  18. Möller H. Why thimerosal allergy? Int J Dermatol 1980; 19: 29.
  19. Wattanakrai P, Rajatanavin N. Thimerosal allergy and clinical relevance in Thailand. J Med Assoc Thai 2007; 90: 1775-9.
  20. Rocha VB, Scherrer MA. Thimerosal: current sources of contact in Brazil. An Bras Dermatol 2014; 89: 376-8.
  21. Holcomb ZE, Van Noord MG, Atwater AR. Gallate Contact dermatitis: product update and systematic review. Dermat 2017; 28: 115-27.
  22. Gupta M, Mahajan VK, Mehta KS, Chauhan PS. Hair dye dermatitis and p-phenylenediamine contact sensitivity: a preliminary report. Indian Dermatol Online J 2015; 6: 241-6.
  23. Palaniappan V, Karthikeyan K, Anusuya S. Dermatological adverse effects of hair dye use: a narrative review. Indian J Dermatol Venereol Leprol 2023: 1-17
  24. de Groot AC. Side-effects of henna and semi-permanent 'black henna' tattoos: a full review. Contact Dermat 2013; 69: 1-25.
  25. Sahu S, Sethy M, Besra L, Sachan S, Kar HK, Devi BK. Clinicoepidemiological profile of allergic contact dermatitis and its correlation with patch testing in a tertiary care center in Eastern India. Cureus 2022; 14: e32119.
  26. Collet E, Jeudy G, Dalac S. Cheilitis, perioral dermatitis and contact allergy. Eur J Dermatol 2013; 23: 303-7.
  27. Getachew M, Tewelde T. Cosmetic use and its adverse events among female employees of Jimma University, Southwest Ethiopia. Ethiop J Health Sci 2018; 28: 717-24.

引用

Teo HG, Syed Nong Chek SR, Tang MM. Contact sensitisation pattern of patients with eczema at the face and neck region: A retrospective study in Kuala Lumpur. Med J Malaysia. 2024 Sep;79(5):525-530.

复制引用 已复制!