Recently, encapsulated follicular variant of papillary thyroid carcinoma has been reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) to emphasize the benign nature of this entity. In our institution, we have assessed 455 patients treated with radioiodine ablation for differentiated thyroid carcinoma and 20 of them were retrospectively found to fulfill the new NIFTP criteria. There was no evidence of metastasis on post radioiodine whole body scans for NIFTP cases and these patients were in remission subsequently. The benign features of these patients' whole body scans and good clinical outcome following treatment further support NIFTP as a low risk thyroid neoplasm.

1. Nikiforov Y E, Seethala R R, Tallini G, Baloch ZW, Basolo F, Thompson LD et al. Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors. JAMA Oncol 2016; 2(8): 1023-9.
2. Ganly I,  Wang L, Tuttle RM, Katabi N, Ceballos GA, Harach HR et al. Invasion rather than nuclear features correlates with outcome in encapsulated follicular tumours: further evidence for the reclassification of the encapsulated papillary thyroid carcinoma follicular variant. Hum Pathol 2015; 46(5): 657-64.
3. Haugen  BR, Alexander EK,   Bible KC,  Doherty GM,  Mandel SJ, Nikiforov YE et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016; 26(1): 1–133.
4. Perros P,  Colley S,  Boelaert K,   Evans C,  Evans RM,  Gerrard Ba G et al. Guidelines for the Management of Thyroid Cancer. Clin Endocrinol (Oxf) 2014; 81(Suppl 1): 1-122.
5. Cho U, Mete O, Kim MH, Bae JS, Jung CK. Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features. Mod Pathol 2017; 30(6): 810-25.
6. Rosario PW, Furtado Mde S, Mourao GF, Calsolari MR. Patients with Papillary Thyroid Carcinoma at Intermediate Risk of Recurrence According to American Thyroid Association Criteria Can Be Reclassified as Low Risk When the Postoperative Thyroglobulin Is Low. Thyroid 2015; 25(11): 1243-48.