Background

Mantle cell lymphoma (MCL) is an uncommon B cell non Hodgkin lymphoma (NHL) and comprises about 3–10% of adult onset of NHL [1]. It affects mainly lymph nodes. Extranodal sites that are commonly involved include the gastrointestinal tract, Waldeyer's ring, lungs and pleura [2]. Primary MCL of palatine to nsil is rare. Extensive review of English literature review revealed 17 previously reported cases [[3], [4], [5], [6]]. We report a rare case of primary MCL of the palatine tonsil.

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2. Swerdlow, S. H., Campo, E., & Seto, M. (2017). Mantle cell lymphoma. In S. H. Swerdlow, E. Campo, N. L. Harris, et al. (Eds.), WHO classification of tumours of haematopoietic and lymphoid tissues (Revised 4th ed., pp. 285–290). International Agency for Research on Cancer (IARC).
3. Dereci, O., Ay, S., Açıkalın, M. F., & Karagulle, M. (2015). Ill-fitting dentures as primary presentation of mantle cell lymphoma: A case report and literature review of the primary mantle cell lymphomas of the hard palate. Journal of Oral and Maxillofacial Pathology, 19, 255–259.
4. Guggisberg, K., & Jordan, R. C. (2010). Mantle cell lymphoma of the oral cavity: Case series and comprehensive review of the literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 109, 98–104.
5. Vasilakaki, T., Tsavari, A., Arkoumani, E., Koulia, K., Manolondaki, A., Marinis, A., et al. (2015). Primary mantle cell lymphoma of the tonsil: An uncommon case. Hellenic Journal of Surgery, 87, 485–487.
6. Rao, R., Dosemane, D., Jaipuria, B., Saha, D., Narayan, M., & Rao, K. S. (2018). Mantle cell lymphoma of the palatine tonsil: A rare case report. Iranian Journal of Otorhinolaryngology, 30, 297–300.
7. Sun, J., Yang, Q., Lu, Z., Miaoxia, H., Li, G., Minghua, Z., et al. (2012). Distribution of lymphoid neoplasms in China: Analysis of 4638 cases according to the World Health Organization classification. American Journal of Clinical Pathology, 138, 429–434.
8. Nair, R., Arora, N., & Mallath, M. K. (2016). Epidemiology of non-Hodgkin’s lymphoma in India. Oncology, 91(1), 18–25.
9. Salaverria, I., Royo, C., Carvajal-Cuenca, A., Clot, G., Navarro, A., Song, J. Y., et al. (2013). CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma. Blood, 121(8), 1394–1402.
10. Rosenwald, A., Wright, G., Wiestner, A., Chan, W. C., Connors, J. M., Campo, E., et al. (2003). The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell, 3(2), 185–197.
11. Holster, E., Dreyling, M., Klapper, W., Gisselbrecht, C., von Hoof, A., Kluin-Nelemans, H. C., et al. (2008). A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. Blood, 111, 558–565.