Utility of Lung Perfusion SPECT/CT in Detection of Pulmonary Thromboembolic Disease: Outcome Analysis

01 January 1970


Tan Teik Hin and Rosmadi Ismail

Abstract

Reference

  1. Bĕlohlávek, J., Dytrych, V., & Linhart, A. (2013). Pulmonary embolism, part I: Epidemiology, risk factors and risk stratification, pathophysiology, clinical presentation, diagnosis and nonthrombotic pulmonary embolism. Experimental & Clinical Cardiology, 18, 129–138.
    https://scholar.google.com/scholar?q=Belohlavek+2013+pulmonary+embolism
  2. Goldhaber, S. Z., Visani, L., & De Rosa, M. (1999). Acute pulmonary embolism: Clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). The Lancet, 353, 1386–1389.
    https://doi.org/10.1016/S0140-6736(99)01079-0
  3. Lang, I. (2015). Chronic thromboembolic pulmonary hypertension: A distinct disease entity. European Respiratory Review, 24, 246–252.
    https://doi.org/10.1183/16000617.0007-2015
  4. Fedullo, P., Kerr, K. M., Kim, N. H., & Auger, W. R. (2011). Chronic thromboembolic pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 183, 1605–1613.
    https://doi.org/10.1164/rccm.201011-1854CI
  5. Moore, A. J. E., Wachsmann, J., Chamarthy, M. R., Panjikaran, L., Tanabe, Y., & Rajiah, P. (2018). Imaging of acute pulmonary embolism: An update. Cardiovascular Diagnosis and Therapy, 8, 225–243.
    https://doi.org/10.21037/cdt.2018.01.02
  6. Konstantinides, S. V., Meyer, G., Becattini, C., Bueno, H., Geersing, G. J., Harjola, V. P., et al. (2020). 2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism. European Heart Journal, 41, 543–603.
    https://doi.org/10.1093/eurheartj/ehz405
  7. Hansen, S. L., de Nijs, R., Mortensen, J., & Berg, R. M. G. (2020). Ventilation-perfusion SPECT versus CTPA in young adult females with suspected pulmonary embolism. European Respiratory Journal, 55, 2000448.
    https://doi.org/10.1183/13993003.00448-2020
  8. Astani, S. A., Davis, L. C., Harkness, B. A., Supanich, M. P., & Dalal, I. (2014). Detection of pulmonary embolism during pregnancy: Comparing radiation doses of CTPA and pulmonary scintigraphy. Nuclear Medicine Communications, 35, 704–711.
    https://scholar.google.com/scholar?q=Astani+2014+pulmonary+embolism+pregnancy
  9. Moradi, F., Morris, T. A., & Hoh, C. K. (2019). Perfusion scintigraphy in diagnosis and management of thromboembolic pulmonary hypertension. Radiographics, 39, 169–185.
    https://doi.org/10.1148/rg.2019180075
  10. Zuckier, L. S., Moadel, R. M., Haramati, L. B., & Freeman, L. M. (2020). Diagnostic evaluation of pulmonary embolism during the COVID-19 pandemic. Journal of Nuclear Medicine, 61, 630–631.
    https://doi.org/10.2967/jnumed.120.245571
  11. Lu, Y., & Macapinlac, H. A. (2020). Perfusion SPECT/CT to diagnose pulmonary embolism during COVID-19 pandemic. European Journal of Nuclear Medicine and Molecular Imaging, 47, 2064–2065.
    https://doi.org/10.1007/s00259-020-04754-1
  12. Mazurek, A., Dziuk, M., Witkowska-Patena, E., Piszczek, S., & Gizewska, A. (2015). The utility of hybrid SPECT/CT lung perfusion scintigraphy in pulmonary embolism diagnosis. Respiration, 90, 393–401.
    https://doi.org/10.1159/000438822
  13. Naydenska, S., Zlatareva, D., Stancheva, B., Smilkova, E., Bilyukov, R., Pencheva, V., et al. (2017). Diagnostic value of perfusion lung scintigraphy in SPECT/CT and computed tomography pulmonary angiography for detection of pulmonary embolism. European Respiratory Journal, 50, 61PA2358.
    https://scholar.google.com/scholar?q=Naydenska+2017+pulmonary+embolism
  14. Soler, X., Kerr, K. M., Marsh, J. J., Renner, J. W., Hoh, C. K., Test, V. J., et al. (2012). Pilot study comparing SPECT perfusion scintigraphy with CT pulmonary angiography in chronic thromboembolic pulmonary hypertension. Respirology, 17, 180–184.
    https://doi.org/10.1111/j.1440-1843.2011.02098.x
  15. Gutte, H., Mortensen, J., Jensen, C. V., Johnbeck, C. B., von der Recke, P., Petersen, C. L., et al. (2009). Detection of pulmonary embolism with combined ventilation-perfusion SPECT and low-dose CT. Journal of Nuclear Medicine, 50, 1987–1992.
    https://doi.org/10.2967/jnumed.109.065573
  16. Wang, L., Wang, M., Yang, T., Wu, D., Xiong, C., & Fang, W. (2020). A prospective comparative study of ventilation-perfusion imaging and SPECT. Journal of Nuclear Medicine, 61, 1832–1838.
    https://doi.org/10.2967/jnumed.120.244053
  17. Thanuja, M., Maimanah, M., & Sara, U. (2020). Diagnosis of pulmonary embolism: A comparison between ventilation/perfusion SPECT/CT and perfusion-only SPECT/CT. Medical Journal of Malaysia, 75, 490–493.
    https://scholar.google.com/scholar?q=Thanuja+2020+pulmonary+embolism
  18. Le Roux, P. Y., Le Gal, G., & Salaun, P. Y. (2020). Lung scintigraphy for pulmonary embolism diagnosis during COVID-19 pandemic. European Journal of Nuclear Medicine and Molecular Imaging, 47, 2499–2500.
    https://doi.org/10.1007/s00259-020-04890-8
  19. Le Roux, P. Y., Robin, P., Delluc, A., Abgral, R., Palard, X., Tissot, V., et al. (2015). Additional value of combining low-dose CT to V/Q SPECT. Nuclear Medicine Communications, 36, 922–930.
    https://doi.org/10.1097/MNM.0000000000000339
  20. Palmowski, K., Oltmanns, U., Kreuter, M., Mottaghy, F. M., Palmowski, M., & Behrendt, F. F. (2014). Diagnosis of pulmonary embolism: Conventional V/Q SPECT is superior. Respiration, 88, 291–297.
    https://doi.org/10.1159/000362974
  21. Kline, J. A., Mitchell, A. M., Kabrhel, C., Richman, P. B., & Courtney, D. M. (2004). Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism. Journal of Thrombosis and Haemostasis, 2, 1247–1255.
    https://doi.org/10.1111/j.1538-7836.2004.00790.x
  22. Le Gal, G., Righini, M., Roy, P. M., Sanchez, O., Aujesky, D., Bounameaux, H., et al. (2006). Prediction of pulmonary embolism in the emergency department: The revised Geneva score. Annals of Internal Medicine, 144, 165–171.
    https://doi.org/10.7326/0003-4819-144-3-200602070-00004
  23. Bajc, M., Schümichen, C., Grüning, T., Lindqvist, A., Le Roux, P. Y., Alatri, A., et al. (2019). EANM guideline for ventilation/perfusion single-photon emission computed tomography (SPECT) for diagnosis of pulmonary embolism and beyond. European Journal of Nuclear Medicine and Molecular Imaging, 46, 2429–2451.
    https://doi.org/10.1007/s00259-019-04450-0
  24. Lu, Y., Lorenzoni, A., Fox, J. J., Rademaker, J., Vander Els, N., Grewal, R. K., et al. (2014). Noncontrast perfusion single-photon emission CT/CT scanning: A new test for the expedited, high-accuracy diagnosis of acute pulmonary embolism. Chest, 145, 1079–1088.
    https://doi.org/10.1378/chest.13-1699
  25. Miniati, M., Pistolesi, M., Marini, C., Di Ricco, G., Formichi, B., Prediletto, R., et al. (1996). Value of perfusion lung scan in the diagnosis of pulmonary embolism: Results of the Prospective Investigative Study of Acute Pulmonary Embolism Diagnosis (PISA-PED). American Journal of Respiratory and Critical Care Medicine, 154, 1387–1393.
    https://doi.org/10.1164/ajrccm.154.5.8912741
  26. Pepke-Zaba, J., Jansa, P., Kim, N. H., Naeije, R., & Simonneau, G. (2013). Chronic thromboembolic pulmonary hypertension: Role of medical therapy. European Respiratory Journal, 41, 985–990.
    https://doi.org/10.1183/09031936.00050412
  27. Bajc, M., Olsson, B., Palmer, J., & Jonson, B. (2008). Ventilation/perfusion SPECT for diagnostics of pulmonary embolism in clinical practice. Journal of Internal Medicine, 264, 379–387.
    https://doi.org/10.1111/j.1365-2796.2008.01939.x
  28. Grüning, T., Drake, B. E., Farrell, S. L., & Nokes, T. (2014). Three-year clinical experience with V/Q SPECT for diagnosing pulmonary embolism: Diagnostic performance. Clinical Imaging, 38, 831–835.
    https://doi.org/10.1016/j.clinimag.2014.06.006
  29. Corbus, H. F., Seitz, J. P., Larson, R. K., Stobbe, D. E., Wooten, W., Sayre, J. W., et al. (1997). Diagnostic usefulness of lung SPET in pulmonary thromboembolism: An outcome study. Nuclear Medicine Communications, 18, 897–906.
    https://doi.org/10.1097/00006231-199709000-00009
  30. Le Duc-Pennec, A., Le Roux, P. Y., Cornily, J. C., Jaffrelot, M., Delluc, A., de Saint-Martin, L., et al. (2012). Diagnostic accuracy of single-photon emission tomography ventilation/perfusion lung scan in the diagnosis of pulmonary embolism. Chest, 141, 381–387.
    https://doi.org/10.1378/chest.11-1781
  31. Kan, Y., Yuan, L., Meeks, J. K., Li, C., Liu, W., & Yang, J. (2015). The accuracy of V/Q SPECT in the diagnosis of pulmonary embolism: A meta-analysis. Acta Radiologica, 56, 565–572.
    https://doi.org/10.1177/0284185114547907
  32. Patel, P., Patel, P., Bhatt, M., Braun, C., Begum, H., Wiercioch, W., et al. (2020). Systematic review and meta-analysis of test accuracy for the diagnosis of suspected pulmonary embolism. Blood Advances, 4, 4296–4311.
    https://doi.org/10.1182/bloodadvances.2020001830
  33. Toney, L. K., Kim, R. D., & Palli, S. R. (2017). The economic value of hybrid single-photon emission computed tomography with computed tomography imaging in pulmonary embolism diagnosis. Academic Emergency Medicine, 24, 1110–1123.
    https://doi.org/10.1111/acem.13237
  34. Tunariu, N., Gibbs, S. J., Win, Z., Gin-Sing, W., Graham, A., Gishen, P., et al. (2007). Ventilation-perfusion scintigraphy is more sensitive than multidetector CTPA in detecting chronic thromboembolic pulmonary disease. Journal of Nuclear Medicine, 48, 680–684.
    https://doi.org/10.2967/jnumed.106.037499
  35. Waxman, A. D., Bajc, M., Brown, M., Fahey, F. H., Freeman, L. M., Haramati, L. B., et al. (2017). Appropriate use criteria for ventilation-perfusion imaging in pulmonary embolism: Summary and excerpts. Journal of Nuclear Medicine, 58, 13N–15N.
    https://jnm.snmjournals.org/content/58/5/13N
  36. Mondal, S., Quintili, A. L., Karamchandani, K., & Bose, S. (2020). Thromboembolic disease in COVID-19 patients: A brief narrative review. Journal of Intensive Care, 8, 70.
    https://doi.org/10.1186/s40560-020-00470-7
  37. Suh, Y. J., Hong, H., Ohana, M., Bompard, F., Revel, M. P., Valle, C., et al. (2021). Pulmonary embolism and deep vein thrombosis in COVID-19: A systematic review and meta-analysis. Radiology, 298, E70–E80.
    https://doi.org/10.1148/radiol.2020203557
  38. Cobes, N., Guernou, M., Lussato, D., Queneau, M., Songy, B., Bonardel, G., et al. (2020). Ventilation/perfusion SPECT/CT findings in different lung lesions associated with COVID-19: A case series. European Journal of Nuclear Medicine and Molecular Imaging, 47, 2453–2460.
    https://doi.org/10.1007/s00259-020-04860-0
  39. Jögi, J., Markstad, H., Tufvesson, E., Bjermer, L., & Bajc, M. (2014). The added value of hybrid ventilation/perfusion SPECT/CT in patients with stable COPD or apparently healthy smokers. International Journal of Chronic Obstructive Pulmonary Disease, 10, 25–30.
    https://doi.org/10.2147/COPD.S73734
  40. Bajc, M., Chen, Y., Wang, J., Li, X. Y., Shen, W. M., & Wang, C. Z. (2017). Identifying the heterogeneity of COPD by V/P SPECT. International Journal of Chronic Obstructive Pulmonary Disease, 12, 1579–1587.
    https://doi.org/10.2147/COPD.S134817
  41. Lynch, D. A., Austin, J. H. M., Hogg, J. C., Grenier, P. A., Kauczor, H. U., Bankier, A. A., et al. (2015). CT-definable subtypes of chronic obstructive pulmonary disease: A statement of the Fleischner Society. Radiology, 277, 192–205.
    https://doi.org/10.1148/radiol.2015141579
  42. Schembri, G. P., Roach, P. J., Bailey, D. L., & Freeman, L. M. (2015). Artifacts and anatomical variants affecting ventilation and perfusion lung imaging. Seminars in Nuclear Medicine, 45, 373–391.
    https://doi.org/10.1053/j.semnuclmed.2015.02.004

Cite

Tan, T.H., Ismail, R. Utility of Lung Perfusion SPECT/CT in Detection of Pulmonary Thromboembolic Disease: Outcome Analysis. Nucl Med Mol Imaging 57, 1–8 (2023). https://doi.org/10.1007/s13139-021-00726-2

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